Importance of the 11β-hydroxysteroid dehydrogenase enzyme in clinical disorders
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چکیده
منابع مشابه
11β-Hydroxysteroid Dehydrogenase Type 1 and the Metabolic Syndrome
In the past few years, efforts are being made to unravel the mechanisms endowed with the metabolic disturbances associated with obesity that predispose to the metabolic syndrome (MetSyn). The special pathogenic role of liver and visceral adipose tissue (VAT) functions has been particularly intriguing, and many hypotheses have been advanced to explain this association. Tissue-specific actions of...
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This manuscript has been retracted by the Editorial Board of Molecular Medicine Reports, following an investigation prompted by the authors of the article mentioned below and the Editor of the Journal, Inflammation. Fig. 1 in this manuscript was reproduced in its entirety from the following study: Gyurkovska V, Stefanova T, Dimitrova P, Danova S, Tropcheva R and Ivanovska N: Tyrosine kinase inh...
متن کاملRegulation of 11β-hydroxysteroid dehydrogenase type 2 by microRNA.
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is selectively expressed in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid receptor. A diminished activity causes salt-sensitive hypertension. The mechanism of the variable and distinct 11β-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) expression in the cortical collecting duct is poorly...
متن کاملEpigenetic regulation of 11β-hydroxysteroid dehydrogenase type 2 expression
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) is selectively expressed in aldosterone target tissues, where it confers aldosterone selectivity for the mineralocorticoid receptor by inactivating 11β-hydroxyglucocorticoids. Variable activity of 11βHSD2 is relevant for blood pressure control and hypertension. The present investigation aimed to elucidate whether an epigenetic mechani...
متن کاملSelection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
BACKGROUND AND PURPOSE Reducing glucocorticoid exposure in the brain via intracellular inhibition of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has emerged as a therapeutic strategy to treat cognitive impairment in early Alzheimer's disease (AD). We sought to discover novel, brain-penetrant 11β-HSD1 inhibitors as potential medicines for the treatment of ...
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ژورنال
عنوان ژورنال: Orvosi Hetilap
سال: 2013
ISSN: 0030-6002,1788-6120
DOI: 10.1556/oh.2013.29558